Original article "Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations" with permission of authors from English into Czech Translated by MD. Ludmila Elek and skorigoval translation and notes added Ing. Marián Fillo.
Load immune system during early development, including the burden of vaccination may lead to permanent damage to brain function and immune function. Experimental evidence suggests that concurrent administration of only two or three immune adjuvants can overcome innate resistance to autoimmunity. In some developed countries, children before the age of 4-6 years of age get in the routine vaccination of 126 antigenic compounds along with high amounts of aluminum (Al) adjuvant. According to the FDA (US Food and Drug Administration = Office for Food and Drug Administration in the USA, similar to a stout Slovak Institute for Drug Control (SIDC) - Ed. Ed.) Evaluating the safety of vaccines often do not include adequate toxicity studies because vaccines are not considered toxic ( toxic) of the substance.
These observations as a whole raise legitimate concerns about the overall safety of current childhood vaccination programs. It should be emphasized several key points in assessing the toxicity of adjuvants in children: children not considering toxicological risks considered as "small adults" because of their different physiology makes them more vulnerable to toxic damage; home goods store hours in adults was Al adjuvant been linked to various severe autoimmune home goods store hours and inflammatory conditions (e.g. "ASIA" home goods store hours = Autoimmune Syndrome Induced by Adjuvants = autoimmune syndrome induced adjuvant), but when children are vaccinated regularly home goods store hours at much greater amount of Al than adults; often assumes that peripheral immune response does not affect brain function. However, it is now clear evidence that there is a bidirectional communication between the nervous and immune system, which plays a key role in regulating immune and brain function. Conversely, were for many autoimmune diseases are included in "Asia" home goods store hours demonstrated disorders neuroimunitní axis about which it is contemplated that are driven home goods store hours by an overactive home goods store hours immune response; those folders neuroimunitní axis, which play a key role in brain development and function of the immune system, are the main target of Al adjuvants.
In summary, research data show that the safety concerns with current immunization practices home goods store hours may actually be necessary. Because that children bear the greatest risk of complications from vaccination, there is an urgent need to carefully evaluate the adverse health effects home goods store hours of vaccination in children.
Aluminum (Al = aluminum) is highly neurotoxic and it was shown that harms prenatal and postnatal (both before and after birth - Ed. Eds.) Development of the brain in humans and experimental animals. home goods store hours [1-2] In addition to its neurotoxic properties of Al is a strong stimulator (irritant) immune system, home goods store hours which is the reason for its use as adjuvant. [3-8] In this regard, it is somewhat home goods store hours surprising that, despite more than 80 years of use with Al adjuvants considered to be safe rather than on the basis of assumptions on the basis of scientific evidence. For example, nothing is known about the toxicology and pharmacokinetics of Al adjuvants in infants and children. [9] On the other hand, it is known that the adult can long-term persistence in the body of Al adjuvants lead to cognitive dysfunctions and autoimmunity. [6] [10] Despite these observations are children in the routine vaccination continue to be regularly exposed home goods store hours to much higher home goods store hours doses than adults Al adjuvants. [3] [11]
Infants and children can not be in the assessment of toxicological risks considered as "small adults" and this adds another reason for concern about the use of neurotoxins, such as Al, in the role of adjuvants in children's vaccines. Yet outline of the scientific literature on toxicology Al shows that the vast majority of previously conducted research and testing related home goods store hours to Al exposure in adults. [12] If only a few doses of vaccines administered to adults, can cause side effects associated with the syndrome of "ASIA" is reasonable in the absence of experimental evidence to assume that the current pediatric vaccination programs, often exceeding 30 vaccinations during the first 4-6 years of life [ 3] [13] are safe for children? The aim of this review is to focus on the mechanism of toxicity Al adjuvant specifically for the developing nervous and immune home goods store hours systems and "ASIA" syndrome, in order to clarify the unsolved and vigorously debated issue.
Before about 15 years ago did Cohen Shoenfeld important observation: "It appears that vaccines tend to affect the nervous system." [14] According Israeliho and collaborators have adjuvants in vaccines - besides their role in eliciting an immune response - the ability itself to cause autoimmune disease. [5] With regard to these claims arising from these discussions, it is necessary to take into loans
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